Self- reported adverse reactions and Ig. E sensitization to common foods in adults with asthma.
PubMed journal article Hypersensitivity reactions to food. on food additives adverse reactions. food reactions--an emerging issue for adults.
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In the present study, subjects with asthma more frequently reported adverse reactions to foods compared to non- asthmatics (5. Ig. E reactivity to the most common foods. These results are in line with data from a previous study by Woods et al. Ig. E sensitization to foods and asthma or allergic disease [2. The data was supported also by the sensitisation patterns of specific- Ig. E for the most common foods found in the present study. We also show that asthmatics reported symptoms from the GI- tract in a greater frequency compared to non- asthmatics and the most common foods causing self- reported symptoms were nuts, fruits, milk dairy products, alcohol, peanuts and shellfish.
The non- asthmatic subjects seem to report adverse reaction to the same food items as asthmatics but at a significantly lower frequency. These data are in the line with previous reports that show a clear relation between food sensitization/allergy and asthma [2. Here, we demonstrate that the most common foods causing self- reported adverse reactions in subjects with asthma, when excluding those with suspected lactose- and gluten- intolerance, are fruits (as apple, kiwi, peach, nectarine), nuts (hazelnut, walnut, brazil nut), almond, peanut, followed by shellfish, milk dairy products, fried/fat food, potato, tomato, egg, flour and fish.
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The main allergens found in the reported fruits and nuts, carry allergens with known cross- reactivity with PR- 1. This, may explain the high prevalence of adverse reactions to these foods, since birch pollen sensitization is very common in Sweden [2. These findings are confirmed in the present study, in which, 3. Thus, birch sensitization could explain the frequent adverse reactions observed following ingestion of birch related foods [2. When testing the subjects included, with the allergen panels for the most common staple foods and nuts (fx. Generally, adults with asthma are significantly more sensitized to any food, compared to non- asthmatics (3. Subjects with asthma are more frequently sensitized to hazelnut, peanut, almond and milk compared to non- asthmatics which is mainly in accordance with the results from self- reported symptoms in this study.
However, the correlation between Ig. E sensitization to specific food items and the symptoms they cause are rather low, but significant. Concerning the staple foods, we show that asthmatic subjects more frequently report symptoms from egg, fish, milk, and wheat as well as soy compared to non- asthmatics and when we exclude subjects with suspected lactose- and gluten- intolerance, we notice an important difference in the results for milk and wheat (Table 2). When excluding subjects with suspicious intolerance to gluten and/or lactose though, the risk of losing some subjects with true allergy is inevitable, however the difference between asthmatics and non- asthmatics still remains.
These results are in the line with previous reports from a Swedish epidemiological survey by Eriksson et al. Europe [2. 7]. Interestingly subjects with asthma report significantly more symptoms in high rates after alcohol ingestion as from wine/beer compared to non- asthmatics (7. When the Ig. E sensitization to birch pollen is taken into consideration, we observe that among both asthmatics and non- asthmatics, birch- related foods are the most common causatives for adverse reactions with hazelnut in the first place (2. Table 2). Ig. E reactivity to hazelnut and birch were also correlated to self- reported symptoms evoked by hazelnut, which is supported by the reported strong correlation between Ig.
E for birch and Ig. E for hazelnut in both asthmatic and non- asthmatic subjects. It is worth to comment that the prevalence of allergic asthma is much higher in the paediatric and adolescent population [3.
Ig. E- sensitization to the different foods and even other allergens may be more strongly connected to allergic asthma in the paediatric population [3. Ig. E sensitization to foods among adults [3. However, as shown in the present study adult asthmatics also have a high frequency of adverse reactions to foods that correlate with their Ig. E sensitization profile. In this study, asthmatics reported more gastrointestinal symptoms during spring, summer and autumn compared to non- asthmatics. It is still not clear if increased asthma symptoms can be related to the increased frequency of gastrointestinal symptoms observed in the present study. The possible seasonal variation in gastrointestinal symptoms may be related to the pollen season where exposure to pollen may increase the reactivity after the ingestion of pollen related food items [2.
IBS [4. 0]. In two other studies, it was demonstrated that asthmatics with allergy to birch pollen experience more symptoms from the gastrointestinal tract, which resemble irritable bowel syndrome (IBS)- like symptoms, during the pollen season [4. It has also been shown that atopic subjects with IBS and self–reported food hypersensitivity had more severe gastrointestinal symptoms when compared to non- atopic subjects with IBS [4. Interestingly, besides the reported symptoms from the birch- pollen related foods, asthmatics reported more gastrointestinal symptoms to fried/fat food, rich in carbohydrate, wine/beer, legumes and spices which would signify that these patients may more frequently suffer from IBS [4. The present study has some limitations that should be taken into consideration. It is well known that self- reported food intolerance yield a much higher prevalence compared to prevalence from performed food challenges and Ig. E data for food allergies [4. However, the comparison between asthmatics and non- asthmatics should still be valid, since we have no reason to believe that the self- reporting accuracy differs between these two groups.
It would also have been of great value to have asked specifically for lactose and gluten intolerance, and not only get input from the free text fields. Nevertheless, the reported symptoms do affect the subjects, whether it is a true allergy or not. The large number of participants in the study makes the findings reliable and fascinating as there are very few studies to date having examined the relation between food hypersensitivity and Ig. E sensitization to the most common foods in adults.
View This Abstract Online; Adverse food reactions--an emerging issue for adults. J Am Diet Assoc. 2011; 111(12):1877-91 (ISSN: 1878-3570) Skypala I. For the treatment of AK in adults.6 In the. Issues in Emerging Health Technologies Issue 61. applications decreased if severe adverse reactions occurred. Including these new and emerging health issue. Prevalence of adverse reactions to food in. Age-related changes in the trachea in healthy adults.
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